Coupled climate models have significant biases in the tropical Indian Ocean (TIO) sea surface temperature (SST). Our study shows that the TIO SST biases can affect the simulated global atmospheric circulation and its spatio-temporal variability on large scales. The response of the spatial variability is related to the amplitude or phase of the circulation bias, depending on the flow regime and spatial scale, while the response of the interannual variability depends on the sign of the SST bias.